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January 17, 2018

Nature

Biotech booms in China

Biotech booms in China

Biotech booms in China, Published online: 17 January 2018; doi:10.1038/d41586-018-00542-3

A surge of investment and innovation mean that careers in the country’s biopharmaceutical industries have never looked more promising.

by Shannon Ellis at January 17, 2018 12:00 AM

Ageing-related receptors resolved

Ageing-related receptors resolved

Ageing-related receptors resolved, Published online: 17 January 2018; doi:10.1038/d41586-017-09032-4

Ageing is a regulated process in which hormones have pivotal roles. Crystal structures of two hormone co-receptors should be informative for drug discovery focused on age-related disorders.

by Makoto Kuro-o at January 17, 2018 12:00 AM

Returning to a revitalized China after research abroad

Returning to a revitalized China after research abroad

Returning to a revitalized China after research abroad, Published online: 17 January 2018; doi:10.1038/d41586-018-00545-0

Materials chemist Yue Hu explains why she decided to return home after completing a PhD at the University of Edinburgh, UK.

by Sarah O'Meara at January 17, 2018 12:00 AM

Molecular mechanism of promoter opening by RNA polymerase III

Molecular mechanism of promoter opening by RNA polymerase III

Molecular mechanism of promoter opening by RNA polymerase III, Published online: 17 January 2018; doi:10.1038/nature25440

RNA polymerase III (Pol III) catalyses the transcription of short RNAs, including transfer RNAs and the 5S ribosomal RNA, which are essential for protein synthesis during cell growth. Pol III is predominantly regulated at the level of transcription initiation, and dysregulated Pol III activity is linked to diseases including cancer. Two independent studies in this issue, by Alessandro Vannini and colleagues and Christoph Müller and colleagues, describe electron cryo-microscopy structures of the yeast Pol III preinitiation complex, comprising the full 17-subunit Pol III and the three TFIIIB subunits (TBP, Brf1 and Bdp1) bound to promoter DNA in various functional states. The structures reveal the detailed mechanisms that underlie how Pol III is recruited to its target promoters and how promoter DNA is opened to form a stable transcription bubble, and also allow a comparison with the structures of Pol I and Pol II preinitiation complexes.

by Christoph W. Müller at January 17, 2018 12:00 AM

Chromosomal instability drives metastasis through a cytosolic DNA response

Chromosomal instability drives metastasis through a cytosolic DNA response

Chromosomal instability drives metastasis through a cytosolic DNA response, Published online: 17 January 2018; doi:10.1038/nature25432

In chromosomally unstable tumour cells, rupture of micronuclei exposes genomic DNA and activates the cGAS–STING cytosolic DNA-sensing pathway, thereby promoting metastasis.

by Lewis C. Cantley at January 17, 2018 12:00 AM

Erratum: Moving beyond microbiome-wide associations to causal microbe identification

Erratum: Moving beyond microbiome-wide associations to causal microbe identification

Erratum: Moving beyond microbiome-wide associations to causal microbe identification, Published online: 17 January 2018; doi:10.1038/nature25471

Erratum: Moving beyond microbiome-wide associations to causal microbe identification

by Dennis L. Kasper at January 17, 2018 12:00 AM

Laws are not the only way to boost immunization

Laws are not the only way to boost immunization

Laws are not the only way to boost immunization, Published online: 17 January 2018; doi:10.1038/d41586-018-00660-y

The French government must mitigate the risks in its legal imposition of vaccinations by promoting more coherent and proactive vaccine policies.

January 17, 2018 12:00 AM

Clonal evolution mechanisms in <i>NT5C2</i> mutant-relapsed acute lymphoblastic leukaemia

Clonal evolution mechanisms in NT5C2 mutant-relapsed acute lymphoblastic leukaemia

Clonal evolution mechanisms in <i>NT5C2</i> mutant-relapsed acute lymphoblastic leukaemia, Published online: 17 January 2018; doi:10.1038/nature25186

Mutations in the nucleotidase-encoding gene NT5C2 drive chemotherapy resistance in relapsed acute lymphoid leukaemia but the mutations also lead to a loss-of-fitness phenotype and to collateral drug sensitivity, which could be exploited for therapy.

by Adolfo A. Ferrando at January 17, 2018 12:00 AM

Baby penguins benefit from fishing bans

Baby penguins benefit from fishing bans

Baby penguins benefit from fishing bans, Published online: 17 January 2018; doi:10.1038/d41586-018-00836-6

South African survey provides rare evidence on fishery impacts.

January 17, 2018 12:00 AM

January 16, 2018

Nature

Train robots to self-certify their safe operation

Train robots to self-certify their safe operation

Train robots to self-certify their safe operation, Published online: 16 January 2018; doi:10.1038/d41586-018-00646-w

Train robots to self-certify their safe operation

by David Lane at January 16, 2018 12:00 AM