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Structural > Crystallization

Bioinformatics tools
Bioinformatics tools from the Israel Structural Proteomics Center.
CLIMS (Laboratory Information Management System) for protein Crystallography that features a novel graphical interface to a relational database, and assists all aspects of protein crystallisation, including: 1) protein expression and handling; 2) crystallisation optimisation; and 3) visualisation of results and preliminary diffraction data.
Crystal Growth 101 literature from Hampton Research
Are you looking to get started in crystallization? Check out some of Hampton Reseearch's Crystal Growth 101 guides to help you.
Crystallization Tips
A collection of crystallization tips from Hampton Research.
DisEMBL is a computational tool for prediction of disordered/unstructured regions within a protein sequence. As no clear definition of disorder exists, we have developed parameters based on several alternative definitions, and introduced a new one based on the concept of ``hot loops'', i.e. coils with high temperature factors.
EGAD: protein design and mutant stability and affinity prediction
EGAD is a free, open-source software package for protein design and prediction of mutation effects on protein folding stabilities and binding affinities to 1kcal/mol. EGAD can also consider multiple structures simultaneously for designing specific binding proteins or locking proteins into specific conformational states. In addition to natural protein residues, EGAD can also consider free-moving ligands with or without rotatable bonds.
FoldIndex tries to answer to the question: Will this protein fold? It's a dynamic and interactive process that estimates the local and general probability for the provided sequence, under specified conditions, to fold.
Intrinsic Protein Disorder, Domain & Globularity Prediction.
HWI High Throughput Crystallization Service
The high-throughput crystallization laboratory at HWI will prepare crystal-growth screening experiments in 1536-well microassay plates free to anyone who will permit the results of the experiment to be added to the HWI crystallization database. This service is otherwise provided for a fee of $1,000 per plate. We will not publicly disclose information on any sample we receive for crystallization trials without the expressed written consent of the investigator(s).
Disordered regions (DRs) are entire proteins or regions of proteins which lack a fixed tertiary structure, essentially being partially or fully unfolded.
POODLE (Prediction Of Order and Disorder by machine LEarning) is a system that predicts disorder regions using amino acid sequence alone. The POODLE system consists of three predictions, short disorder regions prediction, long disorder regions prediction and unfolded protein prediction.
Regional Order Neural Network (RONN) to predict protein disorder.
RaCC (Rare Codon Calculator) determines the number of rare E. coli codon in a given DNA sequence.
The Protein Crystallization Home Page of Terese Bergfors
The Protein Crystallization Page includes a pictorial library of crystallization drop phenomena.
VaZyMolO is a database dealing with viral sequences at the protein level. Its aim is to define modules suitable for high expression, solubility, and crystallization.